Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein kinases 1988: a current perspective.

P J Blackshear1, A C Nairn, J F Kuo

  • 1Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

bioRxiv : the preprint server for biology·2024
Same author

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.

Science advances·2021
Same author

Inhibition of STEP<sub>61</sub> ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Molecular psychiatry·2016
Same author

Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex.

Neuroscience·2010
Same author

Cocaine self-administration in mice is inversely related to phosphorylation at Thr34 (protein kinase A site) and Ser130 (kinase CK1 site) of DARPP-32.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2006
Same author

2-Deoxyglucose and NMDA inhibit protein synthesis in neurons and regulate phosphorylation of elongation factor-2 by distinct mechanisms.

Journal of neurochemistry·2006

Recent protein kinase research reveals new insights into protein serine/threonine kinases, including protein kinase C, and protein tyrosine kinases. Discoveries include novel inhibitors and signaling pathway associations.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Signaling

Background:

  • Protein kinases are crucial enzymes regulating cellular processes.
  • Recent advancements have expanded our understanding of kinase families and their functions.
  • The complexity of kinase regulation and signaling pathways is an active area of research.

Purpose of the Study:

  • To review recent developments in protein serine/threonine kinases and protein tyrosine kinases.
  • To highlight novel findings in kinase structure, function, and regulation.
  • To explore the association between protein tyrosine kinases and phosphatidylinositol kinase activity in signal transduction.

Main Methods:

  • Literature review of recent studies on protein kinases.
  • Analysis of new discoveries in protein kinase C and calcium/calmodulin-dependent protein kinases.

Related Experiment Videos

  • Examination of emerging research on protein tyrosine kinases and their associated activities.

    • Main Results:

    • Protein kinase C family is large, with diverse localization and functions.
    • Calcium/calmodulin-dependent protein kinases play roles in synaptic transmission and protein synthesis.
    • New endogenous kinase inhibitors (pseudosubstrate prototopes) have been identified.
    • Protein tyrosine kinases are rapidly being discovered, with autophosphorylation stimulating activity.
    • Kinase activity is essential for growth factor receptor-mediated cellular effects.
    • A link between protein tyrosine kinases and phosphatidylinositol kinase activity suggests a role in signal transduction.

    Conclusions:

    • Protein kinase research continues to uncover novel enzymes, regulators, and functions.
    • Understanding kinase activity is vital for elucidating complex cellular signaling pathways.
    • The interplay between different kinase families, like tyrosine and phosphatidylinositol kinases, is key to signal transduction.