Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

993
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
993
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

3.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.9K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

947
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
947
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

391
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
391
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.0K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

356
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
356

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associationof Static and Dynamic Pupillary Abnormalities with Retinal Microvasculopathy and Neurodegeneration in Diabetics.

Photodiagnosis and photodynamic therapy·2026
Same author

Elevated N/P Ratios Enhance Arsenic Bioaccumulation and Biotransformation in Marine Microalgae.

Environmental science & technology·2026
Same author

Quality and reliability of online health information on benign paroxysmal positional vertigo in TikTok and Bilibili short videos: A cross-sectional content analysis.

Digital health·2026
Same author

The NRT1.1-NLP7 Nexus: An Integrative Signaling Nexus from Nitrate Sensing to Systemic Adaptation and Structure-Guided Engineering.

Plants (Basel, Switzerland)·2026
Same author

TRIM28-mediated SUMOylation of SREBF1 drives PD‑L1 N‑glycosylation and immune evasion in bladder cancer.

Cell death & disease·2026
Same author

Impact of a pro-inflammatory diet on upper gastrointestinal cancer risk: evidence from a population-based cohort in high-risk areas of China.

European journal of nutrition·2026

Related Experiment Video

Updated: Feb 11, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Zebrafish heart failure models: opportunities and challenges.

Xingjuan Shi1,2,3, Ru Chen4, Yu Zhang4

  • 1Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University, Nanjing, 210096, China. xingjuanshi@seu.edu.cn.

Amino Acids
|May 5, 2018
PubMed
Summary

Zebrafish models, including genetic and chemical-induced, offer insights into heart failure pathogenesis. These models aid in understanding cardiomyopathy and developing new therapeutic targets for cardiovascular diseases.

Keywords:
CardiomyopathyChemical compoundHeart failureMitochondriaSarcomereZebrafish

More Related Videos

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.1K
Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K
Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

2.1K
Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K

Area of Science:

  • Cardiovascular Science
  • Genetics
  • Pharmacology

Background:

  • Heart failure is a complex syndrome resulting from myocardial damage or genetic factors.
  • Cardiomyopathies, often caused by gene mutations, lead to various heart failure pathologies.
  • Zebrafish (Danio rerio) are increasingly used to model human cardiovascular diseases.

Purpose of the Study:

  • To review zebrafish genetic models of heart failure caused by cardiomyopathy.
  • To summarize zebrafish models of heart failure induced by chemical compounds.
  • To enhance understanding of heart failure pathogenesis and identify novel therapeutic targets.

Main Methods:

  • Summarizing existing literature on zebrafish genetic models of cardiomyopathy-induced heart failure.
  • Outlining zebrafish models of heart failure triggered by chemical compounds.
  • Analyzing the utility of these zebrafish models for disease mechanism elucidation.

Main Results:

  • Zebrafish genetic models linked to sarcomere, calcium, and mitochondrial genes are effective for studying heart failure.
  • Chemical compound-induced zebrafish models provide insights into heart failure triggers.
  • These models facilitate the study of congenital heart defects and drug development.

Conclusions:

  • Zebrafish models are valuable tools for investigating the mechanisms of heart failure.
  • Understanding these models can lead to the identification of potential therapeutic strategies for heart failure.
  • Zebrafish research contributes to preclinical drug development for cardiovascular diseases.