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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
Published on: December 19, 2017
Is MRI imaging in pediatric age totally safe? A critical reprisal
Sergio Salerno1, Claudio Granata2, Marco Trapenese3
1Dipartimento di Diagnostica per Immagini, Policlinico Università degli Studi di Palermo, Via del Vespro 127, CAP 90127, Palermo, Italy. sergio.salerno@unipa.it.
Abstract:
Current radiological literature is strongly focussed on radiation imaging risks. Indeed, given there is a small but actual augment in cancer risk from exposure to ionizing radiation in children, it is important to understand what the risk of alternative techniques could be. We retrospectively review literature data concerning possible MR imaging risks, focussing on the biological effects of MR, sedation and gadolinium compound risks when dealing with infant patients. The main concerns can be summarized in: (1) Biological effects of non-ionizing electromagnetic fields (EMF) employed-whose mechanisms of interaction with human tissues are polarization, induced current, and thermal heating, respectively. (2) Risks associated with noises produced during MRI examinations. (3) Hazards from ferromagnetic external and/or implanted devices-whose risk of being unintentionally brought inside MR room is higher in children than in adults. (4) Risks associated with sedation or general anaesthesia, essential problem in performing MR in very young patients, due to the exam long-lasting. (5) Risks related to gadolinium-based contrast agents, especially considering the newly reported brain deposition.
Insights
Magnetic Resonance Imaging (MRI) offers an alternative to radiation imaging for children. This review examines potential MRI risks, including biological effects, sedation, and gadolinium contrast agents, for infant patients.
Area of Science:
- Medical Imaging
- Pediatric Radiology
- Biophysics
Background:
- Current radiological literature emphasizes radiation imaging risks, particularly ionizing radiation exposure in children.
- There is a need to understand the safety profile of alternative imaging techniques for pediatric patients.
Purpose of the Study:
- To retrospectively review literature data on potential risks associated with Magnetic Resonance Imaging (MRI) in infant patients.
- To focus on the biological effects of MRI, sedation, and gadolinium contrast agents in this population.
Main Methods:
- Retrospective review of existing literature data.
- Analysis of biological effects from non-ionizing electromagnetic fields (EMF).
- Assessment of risks related to sedation, anesthesia, ferromagnetic devices, and gadolinium-based contrast agents.
Main Results:
- Potential MRI risks include biological effects of EMF (polarization, induced currents, thermal heating).
- Risks also encompass loud noise, ferromagnetic device hazards, sedation/anesthesia complications, and gadolinium deposition.
- Ferromagnetic device risks are heightened in children due to accidental introduction into the MRI room.
Conclusions:
- Understanding MRI risks is crucial for pediatric imaging, balancing benefits against potential harms.
- Key concerns involve EMF interactions, procedural sedation, and gadolinium contrast agent safety.
- Further research into long-term effects and safer contrast agents is warranted for pediatric MRI.
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