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Updated: Feb 11, 2026

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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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Clinical Inquiries: Does niacin decrease cardiovascular morbidity and mortality in CVD patients?
Peter Lazzopina1, Anne Mounsey1, Lara Handler2
1University of North Carolina Family Medicine Residency, Chapel Hill, USA.
The Journal of Family Practice
|May 5, 2018
Abstract:
No. Niacin doesn't reduce cardiovascular disease (CVD) morbidity or mortality in patients with established disease (strength of recommendation [SOR]: A, meta-analyses of randomized controlled trials [RCTs] and subsequent large RCTs). Niacin may be considered as monotherapy for patients intolerant of statins (SOR: B, one well-done RCT).
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