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In Silico Clinical Trials for Cardiovascular Disease

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Published on: May 27, 2022

Clinical Inquiries: Does niacin decrease cardiovascular morbidity and mortality in CVD patients?

Peter Lazzopina¹, Anne Mounsey¹, Lara Handler²

¹University of North Carolina Family Medicine Residency, Chapel Hill, USA.

The Journal of Family Practice

|May 5, 2018

Summary

This summary is machine-generated.

Niacin (nicotinic acid) does not lower cardiovascular disease (CVD) risks in patients who already have the condition. It may be an option for patients unable to tolerate statins.

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Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

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Area of Science:

Cardiology
Pharmacology
Clinical Trials

Background:

Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
Niacin has been investigated for its potential lipid-modifying effects and cardiovascular benefits.

Purpose of the Study:

To evaluate the efficacy of niacin in reducing cardiovascular disease (CVD) morbidity and mortality in patients with established CVD.
To assess the role of niacin as an alternative therapy for patients with statin intolerance.

Main Methods:

Systematic review and meta-analysis of randomized controlled trials (RCTs).
Inclusion of subsequent large-scale RCTs for robust evidence.
Analysis of data concerning CVD events and patient tolerance to niacin.

Main Results:

Niacin demonstrated no significant reduction in cardiovascular disease (CVD) morbidity or mortality in patients with established CVD (SOR: A).
Evidence from a well-conducted RCT suggests niacin may be considered as monotherapy for patients who cannot tolerate statins (SOR: B).

Conclusions:

Niacin is not recommended for reducing CVD risk in patients with existing cardiovascular disease.
Niacin can be considered as a monotherapy option for individuals experiencing statin intolerance.