Related Experiment Video

Updated: Feb 11, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.3K

Hepatitis B Vaccination Effective in Children Exposed to Anti-Tumour Necrosis Factor Alpha in Utero

Alison de Lima1, Shannon L Kanis1, Johanna C Escher2

  • 1Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, the Netherlands.

Journal of Crohn'S & Colitis
|May 5, 2018
PubMed

Insights

Infants exposed to tumor necrosis factor [TNF] alpha inhibitors in utero demonstrate effective hepatitis B virus [HBV] vaccination responses. Post-vaccination anti-HB levels were comparable between exposed and unexposed children, indicating successful immunization.

Area of Science:

  • Immunology
  • Pediatrics
  • Vaccinology

Background:

  • Neonates exposed to tumor necrosis factor [TNF] alpha inhibitors in utero can have detectable drug levels persisting for up to a year.
  • The hepatitis B virus [HBV] vaccine is a routine childhood immunization in the Netherlands.
  • Adults on anti-TNF therapy may exhibit suboptimal responses to HBV vaccination.

Purpose of the Study:

  • To compare anti-HB levels in children exposed to anti-TNF therapy in utero with those of unexposed children.
  • To assess the efficacy of routine Dutch HBV vaccination in neonates with in utero anti-TNF exposure.

Main Methods:

  • A cross-sectional, controlled cohort study was conducted between 2014 and 2017.
  • Participants included pregnant women with inflammatory bowel disease [IBD] on anti-TNF therapy and their neonates, compared to a control group.
  • Anti-HB levels were measured via enzyme-linked immunosorbent assay one month after the final HBV vaccination dose.

Main Results:

  • No significant difference in anti-HB levels was observed at 12 months between the anti-TNF-exposed group (>1000 IU/l) and the control group (>1000 IU/l) [p = 0.59].
  • All children in both groups achieved successful HBV immunization, defined as anti-HB levels > 10 IU/l.
  • Median anti-TNF levels in cord blood were 9.0 µg/ml for infliximab and 0.4 µg/ml for adalimumab; no differences in birth or health outcomes were noted.

Conclusions:

  • Neonates with in utero exposure to anti-TNF agents can be effectively immunized against hepatitis B virus.
  • Routine HBV vaccination is successful in children born with detectable anti-TNF drug levels.
Abstract

More Related Videos

Murine Bioluminescent Hepatic Tumour Model05:23

Murine Bioluminescent Hepatic Tumour Model

Published on: July 17, 2010

17.8K
Experimental Paradigm for Measuring the Effects of Self-distancing in Young Children07:01

Experimental Paradigm for Measuring the Effects of Self-distancing in Young Children

Published on: March 1, 2019

8.5K

Related Concept Videos

Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
6.7K
Vaccinations01:51

Vaccinations

Overview
51.8K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
599
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.1K
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.7K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K