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Efficacy of intravitreal aflibercept in patients with exudative age-related macular degeneration
Aim Of The Study:
To evaluate the efficacy of intravitreal aflibercept administered to patients with exudative age-related macular degeneration.
Materials And Methods:
70 patients with exudative age-related macular degeneration confirmed clinically and in additional diagnostic procedures (fluorescein angiography and spectral domain-optical coherence tomography) were enrolled. All patients were administered three doses of intravitreal aflibercept at one-month intervals. Some patients (seven) received an additional injection of the drug two months after the last of the three injections. The best-corrected visual acuity and the optical coherence tomography findings were assessed at baseline and after the treatment.
Results:
At baseline, the mean best corrected visual acuity was 0.20. After the injection of aflibercept it improved to the mean value of 0.32 with the difference being statistically significant (p < 0.001, Student's t-test). The mean central subfield thickness at baseline was 311.4 μm. It decreased to mean value of 254.5 pμn with the difference being statistically significant (p<0.001, Student's t-test).
Conclusions:
Intravitreal injections of aflibercept improved clinical and anatomical parameters in patients with exudative age-related macular degeneration in the initial phase of treatment.
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