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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Neuropsychological function in type 2 diabetes mellitus.

Janice Nici1, Jim Hom1

  • 1The Neuropsychology Center, PC , Plano , Texas , USA.

Applied Neuropsychology. Adult
|May 5, 2018
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes mellitus (DM) impairs brain function, affecting neurocognitive and sensorimotor abilities. This study identified a specific neurocognitive profile in DM patients, indicating moderate brain-related impairment.

Keywords:
DiabetesHalstead-Reitan Neuropsychological Test Batteryneurocognitive functionneurological diseasetesting

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Type 2 diabetes mellitus (DM) is a significant global health concern.
  • Previous research indicates DM affects brain structure, dementia risk, and cognitive functions.
  • Understanding DM's neurological impact is crucial for patient management.

Purpose of the Study:

  • To investigate the neurocognitive and sensorimotor effects of type 2 DM in clinically-referred patients.
  • To compare the performance of type 2 DM patients with matched control individuals.
  • To identify a potential neurocognitive profile associated with type 2 DM.

Main Methods:

  • A cohort of clinically-referred type 2 DM patients was compared to a pairwise-matched control group.
  • Participants were matched on age, education, and gender.
  • A comprehensive, integrated neuropsychological test battery was administered to all participants.

Main Results:

  • The type 2 DM group exhibited generalized and specific neuropsychological dysfunction across various abilities.
  • No significant differences were observed in attention, memory, or abstract reasoning between groups.
  • Despite specific unaffected domains, the DM group consistently underperformed on all measures, indicating moderate brain-related impairment (GNDS score).

Conclusions:

  • Type 2 diabetes mellitus is associated with a broad pattern of neurocognitive and sensorimotor deficits.
  • A distinct neurocognitive profile characterizes individuals with type 2 DM.
  • These findings can aid clinicians in understanding and managing the brain-related effects in their DM patients.