Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 11, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

1.3K

Osteosarcopenia.

James Paintin1, Cyrus Cooper2, Elaine Dennison3

  • 1Academic FY2 Doctor, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton SO16 6YD.

British Journal of Hospital Medicine (London, England : 2005)
|May 5, 2018
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent advances in the pathogenesis and treatment of osteoporosis.

Clinical medicine (London, England)·2016
Same author

A systematic review of intervention thresholds based on FRAX : A report prepared for the National Osteoporosis Guideline Group and the International Osteoporosis Foundation.

Archives of osteoporosis·2016
Same author

On epidemiology of fractures and variation with age and ethnicity.

Bone·2016
Same author

Pubertal timing and bone phenotype in early old age: findings from a British birth cohort study.

International journal of epidemiology·2016
Same author

Anti-Osteoporosis Medication Prescriptions and Incidence of Subsequent Fracture Among Primary Hip Fracture Patients in England and Wales: An Interrupted Time-Series Analysis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2016
Same author

The effectiveness of a real life dose reduction strategy for tumour necrosis factor inhibitors in ankylosing spondylitis and psoriatic arthritis.

Rheumatology (Oxford, England)·2016
Same journal

Beyond the High: A Narrative Review of the Chronic Complications of Recreational Ketamine Use.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Prolonged Undiagnosed Prodromal Symptoms.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Human Factors and Deterioration: What Success Factors Facilitate Escalation of Care and How Can These Be Applied More Reliably?

British journal of hospital medicine (London, England : 2005)·2026
Same journal

Comparative Evaluation of Functional Outcomes and Postoperative Complications After Minimally Invasive Fixation for Acromioclavicular Joint Injuries.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

A Systematic Review of Functional MRI Studies on Seasonal Modulation of Brain Functional Connectivity.

British journal of hospital medicine (London, England : 2005)·2026
Same journal

More Than Myocarditis? Cardiac Involvement in Phaeochromocytoma-A Case Report.

British journal of hospital medicine (London, England : 2005)·2026
See all related articles

Osteosarcopenia, the co-occurrence of osteoporosis and sarcopenia, is a growing concern in aging populations. Understanding its multifactorial causes is key to developing holistic treatments for this debilitating bone and muscle condition.

Area of Science:

  • Gerontology
  • Musculoskeletal Health
  • Aging Research

Background:

  • Osteosarcopenia is a syndrome characterized by the simultaneous presence of osteoporosis (low bone mass) and sarcopenia (muscle loss).
  • This dual condition significantly increases the risk of falls, fractures, and institutionalization in the elderly.
  • The aging population amplifies the public health relevance of osteosarcopenia.

Purpose of the Study:

  • To highlight the significance of osteosarcopenia as a public health concern.
  • To emphasize the multifactorial etiology of osteosarcopenia, involving the 'bone-muscle unit'.
  • To advocate for a holistic therapeutic approach targeting both bone and muscle.

Main Methods:

  • Literature review and synthesis of current understanding on osteosarcopenia.

Related Experiment Videos

Last Updated: Feb 11, 2026

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
03:52

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

1.3K
  • Analysis of the interplay between mechanical, biochemical, genetic, and lifestyle factors.
  • Exploration of potential therapeutic strategies.

    • Main Results:

    • Osteosarcopenia presents a greater risk of adverse outcomes compared to either condition alone.
    • The etiology is multifactorial, involving complex interactions within the 'bone-muscle unit'.
    • Current understanding points to the need for integrated treatment strategies.

    Conclusions:

    • A deeper understanding of muscle-bone interactions is crucial for developing novel therapeutic agents.
    • Future treatments should adopt a holistic approach, combining pharmacological, nutritional, and exercise-based therapies.
    • Addressing osteosarcopenia is essential for improving the quality of life in an aging global population.