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In vitro inhibition of human herpesvirus-6 by phosphonoformate
H Z Streicher1, C L Hung, D V Ablashi
1National Cancer Institute, Bethesda, Maryland 20892.
Journal of Virological Methods
|September 1, 1988
Abstract:
HSB-2 cell cultures productively infected with human herpesvirus-6 were treated with the antiviral drugs phosphonoformic acid (PFA), acyclovir (ACV), and gancyclovir (DHPG). ACV and DHPG showed significant toxic effects on uninfected HSB-2 cells, yet only incompletely inhibited viral expression upon infection of the cells. PFA, however, showed little direct toxicity on HSB-2 cells while viral replication was inhibited significantly.