Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

2.4K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
2.4K
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

14.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
14.9K
Critical Region, Critical Values and Significance Level01:16

Critical Region, Critical Values and Significance Level

13.4K
The critical region, critical value, and significance level are interdependent concepts crucial in hypothesis testing.
In hypothesis testing, a sample statistic is converted to a test statistic using z, t, or chi-square distribution. A critical region is an area under the curve in  probability distributions demarcated by the critical value. When the test statistic falls in this region, it suggests that the null hypothesis must be rejected. As this region contains all those values of the...
13.4K
Critical Values01:31

Critical Values

10.4K
A critical value is a definite value obtained from a particular probability distribution at a predecided confidence level (or a predecided significance level) for a given population parameter. The critical value provides demarcation that separates the sample statistics that are likely to occur from the ones that are unlikely to occur based on the given probability distribution and the population parameter to be estimated. The critical value for normal distribution is obtained from the z...
10.4K
Critical Thinking01:19

Critical Thinking

1.2K
Critical thinking involves reflective and productive thinking and the evaluation of evidence. Critical thinkers seek to understand the deeper meaning of ideas, question assumptions, and make independent decisions about what to believe or do. Scientists, for instance, are often critical thinkers. Critical thinking also requires humility about what we know and don't know and the motivation to look beyond the obvious. It is essential for effective problem-solving.
Colleges and universities are...
1.2K
Critical Thinking I01:24

Critical Thinking I

5.2K
Critical thinking helps decision-making and allows nurses to recognize barriers to success and find solutions to possible issues. It helps to brainstorm and implement ideas to achieve goals. Critical thinking helps acknowledge and state workflow inefficiencies while improving management techniques. Nurses understand the value of critical thinking and look for fellow nurses with critical thinking skills to upgrade their professional standards. Critical thinking can advance a nurse's career...
5.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of platelet characteristics on post-transfusion count response in critically ill children on Extracorporeal Membrane Oxygenation: A secondary analysis of the ECSTATIC trial.

Transfusion·2026
Same author

The clinical use of cryoprecipitate and fibrinogen concentrate: A scoping review.

Transfusion·2026
Same author

How do we use smart blood refrigerators at our hospitals in North America?

Transfusion·2026
Same author

Epidemiology of Pediatric Transfusion Reactions.

JAMA network open·2026
Same author

Consensus-based criteria for actionable hemorrhage in pediatric trauma: A Delphi study.

The journal of trauma and acute care surgery·2026
Same author

The Year in Coagulation and Transfusion: Selected Highlights.

Journal of cardiothoracic and vascular anesthesia·2026

Related Experiment Video

Updated: Feb 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K

Platelet Transfusion Practices in Critically Ill Children.

Marianne E Nellis1, Oliver Karam2, Elizabeth Mauer3

  • 1Pediatric Critical Care Medicine, Department of Pediatrics, NY Presbyterian Hospital - Weill Cornell Medicine, New York, NY.

Critical Care Medicine
|May 5, 2018
PubMed
Summary

Platelet transfusions are common in pediatric intensive care units (PICUs), often given prophylactically. Higher doses were linked to increased mortality, suggesting a need for clearer transfusion guidelines in critically ill children.

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.4K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.6K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.4K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

10.0K

Area of Science:

  • Pediatric critical care medicine
  • Hematology
  • Transfusion medicine

Background:

  • Platelet transfusions are frequently administered in pediatric intensive care units (PICUs).
  • Limited data exists on the epidemiology, indications, and outcomes of platelet transfusions in critically ill children.

Purpose of the Study:

  • To describe the epidemiology, indications, and outcomes of platelet transfusions in critically ill children.
  • To investigate the association between platelet transfusion practices and intensive care unit (ICU) mortality.

Main Methods:

  • A prospective, multicenter, international cohort study was conducted.
  • Data was collected from 82 PICUs across 16 countries between September 2016 and April 2017.
  • Included were children aged 3 days to 16 years receiving platelet transfusions in the ICU.

Main Results:

  • A total of 559 out of 16,934 eligible patients (3.3%) received platelet transfusions.
  • Prophylaxis was the most common indication (67%), followed by minor bleeding (21%) and major bleeding (12%).
  • Higher administered platelet doses were independently associated with increased ICU mortality (OR 1.002 per mL/kg).

Conclusions:

  • Most platelet transfusions in critically ill children are given prophylactically, often with varying platelet count thresholds.
  • Further research is needed to establish appropriate indications for platelet transfusions, particularly for prophylactic use.
  • The study highlights a potential association between increased platelet dose and mortality, warranting further investigation into optimal transfusion strategies.