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Updated: Feb 11, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.5K

Greater attention should be paid to developing therapies for elderly patients with Hodgkin lymphoma-A

Magnus Björkholm1, Caroline E Weibull2, Sandra Eloranta3

  • 1Department of Medicine, Division of Hematology, Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden.

European Journal of Haematology
|May 5, 2018
PubMed

Insights

Older adults over 50 represent a significant portion of Hodgkin lymphoma patients, facing poorer outcomes and underrepresentation in clinical trials. This study highlights their unmet medical needs and advocates for increased trial inclusion.

Area of Science:

  • Oncology
  • Hematology
  • Epidemiology

Background:

  • A substantial proportion (40%) of Hodgkin lymphoma (HL) patients are diagnosed over 50 years old.
  • Older HL patients exhibit significantly worse prognoses compared to younger counterparts.
  • Elderly patients are infrequently enrolled in clinical trials, limiting evidence-based treatment strategies.

Purpose of the Study:

  • To analyze survival outcomes in elderly Hodgkin lymphoma patients.
  • To assess trends in survival and patient characteristics over time.
  • To underscore the need for improved clinical trial access for older adults.

Main Methods:

  • Utilized data from the Swedish Cancer and Lymphoma Registries.
  • Included 7997 Hodgkin lymphoma patients diagnosed between 1973 and 2013.
  • Estimated relative survival ratios (RSRs) stratified by age and sex.

Main Results:

  • Survival rates significantly decrease with advancing age, particularly for those over 70.
  • No substantial improvements in survival were observed for patients aged 45-69 between 2000-2013.
  • Modest survival improvements were noted for patients aged 70 and older during the same period.
  • Patient and disease characteristics remained consistent across the study period.

Conclusions:

  • Elderly Hodgkin lymphoma patients represent a demographic with significant unmet medical needs.
  • Findings support a more proactive strategy for incorporating older patients into clinical trials.
  • This research establishes a crucial baseline for evaluating new therapies, including targeted drugs, in the elderly population.
Abstract

Keywords:
Hodgkin lymphomaelderlyrelative survivaltemporal trends

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