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Single-Cell (Multi)omics Technologies.

Lia Chappell1, Andrew J C Russell1, Thierry Voet1,2

  • 1Wellcome Sanger Institute, Cambridge CB10 1SA, United Kingdom; email: lc5@sanger.ac.uk , ar19@sanger.ac.uk , tv2@sanger.ac.uk.

Annual Review of Genomics and Human Genetics
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Summary
This summary is machine-generated.

Single-cell multiomics integrates multiple molecular data types from individual cells, offering deeper insights into cellular heterogeneity and disease mechanisms than traditional methods. This review covers current and emerging technologies, their applications, and future directions.

Keywords:
cellular heterogeneitymultiomicsomicssingle cell

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Area of Science:

  • Biotechnology
  • Genomics
  • Molecular Biology

Background:

  • Single-cell multiomics measures diverse molecular data from the same cell, surpassing single-omic analyses.
  • It reveals cellular heterogeneity across molecular layers and their interconnections.
  • Understanding these links is crucial for normal development, aging, and disease research.

Purpose of the Study:

  • To review established and novel single-cell mono- and multiomics technologies.
  • To discuss the limitations and applications of these advanced techniques.
  • To explore future developments in the field of single-cell multiomics.

Main Methods:

  • Review of existing literature on single-cell omics technologies.
  • Analysis of established and emerging mono- and multiomics platforms.
  • Discussion of technological capabilities, limitations, and applications.

Main Results:

  • Single-cell multiomics provides a comprehensive view of cellular states and heterogeneity.
  • Coupling and uncoupling of molecular variations can be elucidated.
  • These technologies are vital for understanding complex biological systems.

Conclusions:

  • Single-cell multiomics significantly enhances biological insight and understanding of cellular heterogeneity.
  • Continued technological development promises deeper mechanistic understanding of health and disease.
  • The field is rapidly evolving with significant potential for future discoveries.