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Updated: Feb 11, 2026

Confocal Microscopy to Measure Three Modes of Fusion Pore Dynamics in Adrenal Chromaffin Cells
Published on: March 16, 2022
Direct Visualization of Wide Fusion-Fission Pores and Their Highly Varied Dynamics
Katherine W Eyring1, Richard W Tsien1
1Department of Neuroscience and Physiology, Neuroscience Institute, New York University, New York, NY 10016, USA.
Abstract:
In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-actin-mediated pore expansion.
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