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Updated: Feb 11, 2026

Analysis of Side Population in Solid Tumor Cell Lines
Published on: February 23, 2021
Prognostic value of PEG10 in Asian solid tumors: A meta-analysis
1Department of Gastrointestinal Surgery, The First people's Hospital of Zunyi, Zunyi Medical University, Zunyi, Guizhou, PR China.
Background:
The involvement of paternally expressed gene 10 (PEG10) in the development of solid tumors has been demonstrated. However, the available data have not yet been fully analyzed. We conducted this meta-analysis to evaluate the correlations between PEG10 and the clinicopathological characteristics in patients with solid tumors.
Methods:
An electronic search for relevant articles was conducted in PubMed, Web of Science, Cochrane Library, EMBASE, Chinese CNKI, and Wan Fang. The relationships between PEG10 and the clinicopathological features and prognosis of patients with cancer were determined using pooled odds ratios and hazard ratios with 95% confidence interval (CI).
Results:
Ten studies comprising 1014 patients were included. The pooled analyses indicated the significant association of PEG10 overexpression with the risk of cancer, differentiation, lymph node metastasis and advanced TNM stage, but not with gender in cancer patients. Moreover, a high level of PEG10 expression correlated with poor prognosis and could be used as an independent prognostic biomarker for patients with solid tumors.
Conclusions:
PEG10 expression is associated with advanced clinicopathological characteristics and can be used as a prognostic biomarker in patients with solid tumors.
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