Protocol incorporating airway CT decreases negative bronchoscopy rates for suspected foreign bodies in pediatric

Omar G Ahmed1, Robert P Guillerman2, Carla M Giannoni1

  • 1Texas Children's Hospital, Otolaryngology, Houston, TEXAS, USA; Baylor College of Medicine, Otolaryngology, Houston, TEXAS, USA.

Insights

Selective low-dose computed tomography (CT) significantly reduces negative bronchoscopy rates in children with suspected foreign body aspiration (FBA). This imaging approach enhances diagnostic accuracy and lowers risks associated with unnecessary procedures.

Area of Science:

  • Pediatric Pulmonology
  • Medical Imaging
  • Emergency Medicine

Background:

  • Foreign body aspiration (FBA) is a critical cause of mortality in young children.
  • Direct laryngoscopy and bronchoscopy (DL&B) is the standard diagnostic tool but has a high rate of negative findings.
  • Unnecessary DL&B exposes children to significant operative, anesthetic, and financial risks.

Purpose of the Study:

  • To evaluate the effectiveness of a clinical care protocol using low-dose non-contrast airway computed tomography (CT) in reducing negative bronchoscopy rates.
  • To assess the diagnostic performance of airway CT in identifying pediatric airway foreign bodies.

Main Methods:

  • Implementation of a clinical care protocol involving selective low-dose non-contrast airway CT for intermediate-risk FBA cases.
  • Retrospective review comparing negative bronchoscopy rates before and after protocol implementation.
  • Analysis of airway CT's diagnostic performance characteristics for foreign bodies.

Main Results:

  • The negative bronchoscopy rate decreased from 37% to 17% after protocol implementation (p=0.06).
  • Airway CT demonstrated high diagnostic accuracy: 91% sensitivity, 100% specificity, 100% positive predictive value, and 97% negative predictive value for foreign bodies.

Conclusions:

  • Selective use of low-dose non-contrast airway CT in a clinical protocol effectively reduces negative bronchoscopy rates in children.
  • This imaging strategy significantly lowers operative risks and healthcare costs associated with suspected FBA.
Abstract

Related Concept Videos

Decreased pulse rate01:14

Decreased pulse rate

Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
There are specific risk factors that can elevate the likelihood of developing bradycardia. Advanced age is a significant factor, with...
918
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
1.1K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
274
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
330
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
245
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
307