Serum Corin Level Is Associated With Subsequent Decline in Renal Function in Patients With Suspected Coronary Artery
Shang-Feng Yang1,2, Ruey-Hsing Chou3,4,2, Szu-Yuan Li5,2
1Division of Nephrology, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
Insights
Lower serum corin levels predict progressive renal dysfunction in patients undergoing coronary angiography. This finding highlights corin
Area of Science:
- Cardiology
- Nephrology
- Biomarkers
Background:
- Chronic cardiac dysfunction contributes to progressive renal dysfunction.
- Higher circulatory corin is linked to better cardiovascular outcomes.
- The role of serum corin in contrast-induced nephropathy and renal outcomes is unclear.
Purpose of the Study:
- To investigate serum corin as a predictor of short-term and long-term renal outcomes.
- To assess corin's role in contrast exposure following coronary angiography.
Main Methods:
- 401 patients undergoing coronary angiography were enrolled.
- Serum corin levels were measured pre-procedure.
- Renal outcomes (contrast-induced nephropathy, progressive renal dysfunction) were assessed over at least 1-year follow-up.
Main Results:
- Contrast-induced nephropathy occurred in 5.7% of patients.
- Progressive renal dysfunction occurred in 11.0% of patients.
- Lower baseline serum corin independently predicted higher risk of progressive renal dysfunction (HR 0.23), but not contrast-induced nephropathy.
Conclusions:
- Lower baseline serum corin is associated with an increased risk of renal function decline after coronary angiography.
- This association persists in patients with chronic kidney disease, coronary artery disease, or heart failure.
- Further research is warranted to validate these findings.
Background:
Higher circulatory corin in patients with cardiac diseases is associated with improved cardiovascular outcomes, and chronic cardiac dysfunction is a well-known cause of progressive renal dysfunction. This study aimed to determine the role of serum corin in predicting short-term and long-term renal outcomes after contrast exposure in patients with suspected coronary artery disease.
Methods And Results:
Four hundred one patients who had received coronary angiography were enrolled. Serum corin levels were determined before administration of contrast media. Contrast-induced nephropathy was defined as a rise in serum creatinine of 0.5 mg/dL or a 25% increase from baseline within 48 hours after the procedure. Progressive renal dysfunction was defined as >50% decrease in estimated glomerular filtration rate after discharge. All patients were followed up for at least 1 year or until the occurrence of death after coronary angiography. Overall, contrast-induced nephropathy occurred in 23 (5.7%) patients. During a median follow-up of 529 days, 44 (11.0%) cases had subsequent decline in renal function. After adjustment for demographic characteristics, kidney function, traditional risk factors, and medications, lower corin level was found to be independently associated with higher risk for progressive renal dysfunction (hazard ratio, 0.23; 95% confidence interval, 0.12-0.44) but not for contrast-induced nephropathy. This inverse correlation remained evident in patients with underlying chronic kidney disease, coronary artery disease, or heart failure.
Conclusions:
Lower baseline serum corin was associated with higher risk of renal function decline in patients undergoing coronary angiography. Further studies are needed to verify these results.
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