Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.8K
Overview
51.8K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

459
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
459
Behavior Therapy01:22

Behavior Therapy

732
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
732
Drug Therapy01:28

Drug Therapy

304
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
304

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Daratumumab in high-risk MGUS and low-risk smoldering myeloma: results of the Phase II D-PRISM study.

Nature communications·2026
Same author

Anti-B-cell Maturation Antigen Chimeric Antigen Receptor T-cell Therapy bb21217 for Relapsed and Refractory Multiple Myeloma: Results from the Phase I CRB-402 Study.

Cancer immunology research·2026
Same author

A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma.

Nature cancer·2026
Same author

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma.

Blood cancer discovery·2025
Same author

CAR-T cell therapy for multiple myeloma: An update on the current state and future potential.

Best practice & research. Clinical haematology·2025
Same author

Cancer vaccines in hematologic malignancy: A systematic review of the rational and evidence for clinical use.

Best practice & research. Clinical haematology·2025

Related Experiment Video

Updated: Feb 11, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
08:32

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

7.5K

Vaccine therapy in hematologic malignancies.

David Avigan1, Jacalyn Rosenblatt1

  • 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

Blood
|May 6, 2018
PubMed
Summary
This summary is machine-generated.

Cancer vaccines aim to overcome tumor tolerance by activating tumor-specific lymphocytes. Strategies like dendritic cell/tumor fusions and post-transplant vaccination show promise for durable immune responses against cancer.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.8K

Related Experiment Videos

Last Updated: Feb 11, 2026

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish
08:32

Isolating Malignant and Non-Malignant B Cells from lck:eGFP Zebrafish

Published on: February 22, 2019

7.5K
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

21.1K
Expression and Purification of Virus-like Particles for Vaccination
06:17

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

22.8K

Area of Science:

  • Oncology
  • Immunology
  • Cancer Vaccines

Background:

  • Immune-based therapy represents a significant advancement in cancer treatment, yielding dramatic responses in previously untreatable cancers.
  • Cancer vaccines are being developed to overcome tumor-induced immune tolerance and enhance anti-tumor immune responses.
  • While single-antigen vaccines show some clinical effects, broader efficacy may require multi-antigen approaches and potent antigen-presenting cells.

Purpose of the Study:

  • To explore strategies for developing effective cancer vaccines.
  • To investigate the potential of whole cell-based vaccine approaches, such as dendritic cell/tumor fusions.
  • To evaluate the feasibility of cancer vaccination in the post-transplant setting.

Main Methods:

  • Development of cancer vaccines targeting tumor-specific lymphocytes.
  • Utilizing whole cell-based strategies, including dendritic cell/tumor fusions.
  • Investigating vaccination in the post-transplant setting to leverage cytoreduction and immune modulation.
  • Exploring integration with other immunotherapies and tumor microenvironment-targeting agents.

Main Results:

  • Individual antigen-based vaccines have shown some immune responses and clinical effects.
  • Whole cell-based strategies like dendritic cell/tumor fusions have produced promising results in preliminary studies.
  • The post-transplant setting appears conducive to vaccination due to reduced immunosuppressive factors.

Conclusions:

  • Cancer vaccines hold significant potential for treating intractable cancers by disrupting immune tolerance.
  • Multi-antigen presentation and potent antigen-presenting cells are crucial for broader vaccine efficacy.
  • Whole cell-based vaccines and post-transplant vaccination strategies warrant further investigation in randomized trials for durable clinical impact.