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Updated: Feb 11, 2026

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
Chimeric antigen receptor T cell therapy in pancreatic cancer: from research to practice
Vishal Jindal1, Ena Arora2, Muhammad Masab3
1Department of Internal Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, 01608, USA. vishaljindal87@gmail.com.
Abstract:
Chimeric antigen receptor (CAR) T cell therapy is genetically engineered tumor antigen-specific anticancer immunotherapy, which after showing great success in hematological malignancies is currently being tried in advanced solid tumors like pancreatic cancer. Immunosuppressive tumor microenvironment and dense fibrous stroma are some of the limitation in the success of this novel therapy. However, genetic modifications and combination therapy is the topic of the research to improve its efficacy. In this article, we summarize the current state of knowledge, limitations, and future prospects for CAR T cell therapy in pancreatic cancer.
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