Related Experiment Video

Updated: Feb 11, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.1K

Liver injury after pulsed methylprednisolone therapy in multiple sclerosis patients

Viviana Nociti1,2, Marco Biolato3, Chiara De Fino1

  • 1Multiple Sclerosis Center, Neuroscience Area, Neuroscience, Aging, Head and Neck and Orthopaedics Sciences Department, Fondazione Policlinico Universitario Gemelli, Catholic University of Sacred Heart, Rome, Italy.

Brain and Behavior
|May 6, 2018
PubMed
Abstract

Insights

Liver injury is a notable risk for multiple sclerosis (MS) patients receiving high-dose pulsed methylprednisolone. Monitoring liver function post-treatment is recommended to detect potential adverse effects.

Area of Science:

  • Neurology
  • Hepatology
  • Pharmacology

Background:

  • High-dose pulsed methylprednisolone is a common treatment for multiple sclerosis (MS) relapses.
  • Previous reports suggest a link between this therapy and liver injury, but prospective data in MS patients are lacking.

Purpose of the Study:

  • To prospectively evaluate the prevalence and severity of liver injury in multiple sclerosis patients undergoing pulsed methylprednisolone therapy.

Main Methods:

  • A prospective observational study was conducted on 175 MS patients receiving 1,000 mg/day of intravenous methylprednisolone for 5 days.
  • Liver function tests were performed before and two weeks after treatment.
  • Severe liver injury was defined by Hy's law, prompting further hepatologic evaluation.

Main Results:

  • Out of 251 treatment cycles, 8.6% of patients showed liver injury post-treatment.
  • Severe liver injury, as per Hy's law, occurred in 2.5% of patients.
  • Hepatologic workup identified drug-induced liver injury in three patients and autoimmune hepatitis in three others.

Conclusions:

  • Liver injury is a significant concern in MS patients treated with pulsed methylprednisolone.
  • Regular monitoring of aminotransferase levels before and two weeks after therapy is advisable.
Keywords:
liver injurymultiple sclerosisrelapsesteroids

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.8K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K

Related Concept Videos

Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
2.2K
Pulse01:05

Pulse

The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
4.2K
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
1.8K
Pulse Oximetry01:24

Pulse Oximetry

Pulse oximetry, or SpO2, is a non-invasive method for continuously monitoring arterial oxygen saturation (SaO2). This procedure involves attaching a probe or sensor to the patient's fingertip, forehead, earlobe, or nose bridge. The sensor works by detecting changes in oxygen saturation levels through light signals generated by the oximeter and reflected by the pulsing blood under the probe.
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
1.4K
Regulation of Pulse01:20

Regulation of Pulse

Pulse regulation involves physiological mechanisms that ensure adequate blood flow throughout the body. The heartbeat, regulated by the autonomic nervous system, is influenced by hormonal balance, physical activity, and emotional state.
2.3K
Pulse rhythm01:30

Pulse rhythm

Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.4K