Correlations between lipid metabolism indices in patients with hypertension and hypothyroidism

Introduction: Hypertension is a major reason behind morbidity, disability and mortality. Elevated blood pressure is a huge risk factor for cardio-vascular diseases. Almost 90% of hypertension patients have internal comorbidities, in particular hypothyroidism. For now, however, the specificities of the clinical course of hypertension in hypothyroid patients are understudied and the data on lipid metabolism in patients with primary hypothyroidism and hypertension are inconclusive. The study aims at establishing the effect of the lipid metabolism indices in hypertensive patients with hypothyroidism using correlation analysis.

Materials and methods: The total of 198 patients with stage 1 and stage 2 hypertension were examined. The patients were divided into two groups based on whether they have hypothyroidism or normal thyroid function.

Results: The study revealed that in patients with hypertension and hypothyroidism, hypercholesterolemia is associated with hypocoagulation, hyperkalaemia, decreased bilirubin levels and adrenal cortex activation. Hyperbetalipoproteinemia is linked to the reduced thyroid gland, activation of the lymphocytic component of the inflammatory response, predisposition to hypocoagulation, probable unfavourable acute stress response and development of the eccentric hypertrophy of the left ventricle myocardium. Elevated triglycerides have an effect on the progression of arterial hypertension and are associated with diastolic dysfunction of the left ventricle and hepatic dysfunction.

Conclusion: The combination of hypothyroidism and hypertension is an unfavourable factor in the development and progression of dyslipidaemia, which, in its turn, can cause blood coagulation disorders, adrenal glands activation, cardiac, renal and hepatic damage, and negative adaptive responses.