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Updated: Feb 11, 2026
Detection of Functional Matrix Metalloproteinases by Zymography
Published on: November 8, 2010
Potential roles of circulating matrix metalloproteinase-28 (MMP-28) in patients with atrial fibrillation
Gao Zhan1, Ge Wenhua1, Hu Jie1
1Department of cardiology, the first affiliated hospital of Wenzhou Medical University, Wenzhou, China.
Aims:
Atrial fibrillation is the most common heart disease. Previous research has found that several members of the matrix metalloproteinase (MMP) family are involved. However, the role of the most recently discovered member of the MMP family, MMP-28, has not been fully investigated. The present study aimed to reveal the role of MMP-28 in atrial fibrillation.
Main Methods:
254 patients with sinus rhythm, paroxysmal atrial fibrillation, or persistent atrial fibrillation were enrolled in this prospective observational study. Circulating MMP-28, echocardiography, and other clinical variables were measured at hospital admission. Patients were followed for up to 7 months, and the end-point was occurrence of heart failure.
Key Findings:
MMP-28 was significantly higher in patients with atrial fibrillation than with sinus rhythm, and MMP-28 level was correlated with left atrial diameter. Additionally, MMP-28 independently predicted follow-up heart failure. Other clinical risk factors were previous myocardial infarction, brain natriuretic peptide, persistent atrial fibrillation, and left atrial diameter. MMP-28 increased the performance of prognostic prediction of heart failure.
Significance:
Circulating MMP-28 was elevated in atrial fibrillation. MMP-28 may be related to atrial fibrillation and heart failure.
Insights
Matrix metalloproteinase-28 (MMP-28) is elevated in atrial fibrillation patients and may predict heart failure. This finding offers new insights into atrial fibrillation pathogenesis and heart failure risk.
Area of Science:
- Cardiology
- Biochemistry
- Molecular Biology
Background:
- Atrial fibrillation is a prevalent cardiac arrhythmia.
- Matrix metalloproteinases (MMPs) are implicated in cardiovascular diseases.
- The specific role of MMP-28 in atrial fibrillation remains largely uncharacterized.
Purpose of the Study:
- To investigate the association between MMP-28 and atrial fibrillation.
- To determine if MMP-28 can predict heart failure in patients with atrial fibrillation.
Main Methods:
- Prospective observational study of 254 patients (sinus rhythm, paroxysmal atrial fibrillation, persistent atrial fibrillation).
- Measurement of circulating MMP-28 and echocardiographic parameters at admission.
- Follow-up for up to 7 months to assess heart failure occurrence.
Main Results:
- MMP-28 levels were significantly higher in patients with atrial fibrillation compared to sinus rhythm.
- MMP-28 levels correlated with left atrial diameter.
- MMP-28 independently predicted heart failure, improving prognostic performance.
Conclusions:
- Elevated circulating MMP-28 is observed in atrial fibrillation.
- MMP-28 shows a potential link to the pathophysiology of atrial fibrillation and heart failure development.
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