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Single Step Double-walled Nanoencapsulation (SSDN).

Aharon Azagury1, Vera C Fonseca1, Daniel Y Cho1

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Summary
This summary is machine-generated.

A novel, rapid method creates double-walled (DW) polymeric nanospheres using sequential precipitation. This technique offers a simpler, faster alternative for producing distinct core-shell nanostructures for drug delivery applications.

Keywords:
AFMDSCDouble-walled nanoparticlesNanoparticles production methodPolymers' mixtures

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Conventional methods for producing double-walled (DW) nanoparticles (NPs) are often complex, time-consuming, and prone to aggregation or heterogeneous coating formation.
  • Existing techniques struggle with scalability and achieving distinct core-shell morphologies.

Purpose of the Study:

  • To present a rapid, spontaneous self-assembly method for fabricating double-walled (DW) polymeric nanospheres.
  • To demonstrate the versatility of this method for various polymer combinations and drug encapsulation.

Main Methods:

  • Sequential precipitation of two polymers driven by engineered phase inversions.
  • Characterization using laser diffraction particle sizing, scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).
  • In vitro drug release studies using insulin as a model therapeutic agent.

Main Results:

  • Successfully fabricated DW polymeric nanospheres with distinct core-shell structures.
  • AFM confirmed the presence of a core polymer coated by a shell polymer.
  • Insulin release exhibited a tri-phasic profile over two months, indicating controlled release capabilities.

Conclusions:

  • The presented method provides a rapid, efficient, and scalable approach for producing DW nanospheres with controlled morphology.
  • This technique overcomes limitations of current methods, offering advantages in simplicity and avoiding aggregation.
  • The developed DW nanospheres are suitable for encapsulating therapeutic drugs, with potential for various biomedical applications.