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Updated: Feb 11, 2026

Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
Published on: December 27, 2024
Improved anticancer properties of stem cells derived exosomes by prolonged release from PCL nanofibrous structure
Zahra Rezaie1, Abdolreza Ardeshirylajimi2, Mahmood Dehghani Ashkezari1
1Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran.
Abstract:
Systemic chemotherapy as a routine method for the treatment of cancers has several complications. Localized chemotherapy can significantly increase the treatment efficacy and reduce side effects. Here, mesenchymal stem cells derived microvesicles (MVs) was incorporated into Polycaprolactone nanofibers and then the apoptotic behavior of MCF-7 breast cancer cells was investigated while cultured on MVs-Polycaprolactone by using SEM, MTT and apoptotic gene expression. Results demonstrated that MVs-Polycaprolactone group was shown a great apoptosis induction potential into MCF-7 cells and it can be concluded that MVs-Polycaprolactone has a great promising potential to introduce as an in-situ tumor inhibitor construct rather than chemo-drugs.
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