Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Conformity

Conformity

Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...

Amyloid Fibrils

Amyloid Fibrils

The Evidence for Evolution

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.

Convergent Evolution

Convergent Evolution

Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.

Conformations of Butane

Conformations of Butane

Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prognostic value of circulating tumor DNA in pancreatic cancer: a systematic review and meta-analysis.

Aging·2020

Same author

The role of ferroptosis regulators in the prognosis, immune activity and gemcitabine resistance of pancreatic cancer.

Annals of translational medicine·2020

Same author

The vascular endothelial growth factor trap aflibercept induces vascular dysfunction and hypertension via attenuation of eNOS/NO signaling in mice.

Acta pharmacologica Sinica·2020

Same author

MBNL1 regulates isoproterenol-induced myocardial remodelling in vitro and in vivo.

Journal of cellular and molecular medicine·2020

Same author

Platelets Stimulate Liver Regeneration in a Rat Model of Partial Liver Transplantation.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2020

Same author

Mutant p53 in Cancer Progression and Targeted Therapies.

Frontiers in oncology·2020

Same journal

Tomogram exploration through template matching and deep learning.

Current opinion in structural biology·2026

Same journal

A comparative review of cryo-electron ptychography: Biological applications and future perspectives.

Current opinion in structural biology·2026

Same journal

Metabolic disruptions through a three-dimensional genomic lens.

Current opinion in structural biology·2026

Same journal

Collective variable design for biomolecular conformational dynamics.

Current opinion in structural biology·2026

Same journal

Polymer scaling in protein crowding: From dilute coils to semidilute meshes.

Current opinion in structural biology·2026

Same journal

Tuning the physicochemical properties of rationally designed protein-based biomolecular condensates.

Current opinion in structural biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 11, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

Conformational evolution of polymorphic amyloid assemblies.

Chen Liang¹, Ming-Chien Hsieh¹, Noel X Li¹

¹Department of Chemistry, Emory University, Atlanta, GA 30322, United States.

Current Opinion in Structural Biology

|May 6, 2018

Summary

This summary is machine-generated.

Amyloid assemblies exhibit diverse structures, complicating therapies. This review proposes "conformational evolution," where amyloid structures change and adapt during assembly, influencing disease and biomaterial development.

More Related Videos

Molecular Evolution of the Tre Recombinase

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Evolution of Staircase Structures in Diffusive Convection

Evolution of Staircase Structures in Diffusive Convection

Published on: September 5, 2018

Related Experiment Videos

Last Updated: Feb 11, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

Molecular Evolution of the Tre Recombinase

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Evolution of Staircase Structures in Diffusive Convection

Evolution of Staircase Structures in Diffusive Convection

Published on: September 5, 2018

Area of Science:

Biochemistry
Biomaterials Science
Structural Biology

Background:

Amyloid assemblies display significant morphological diversity, hindering therapeutic development and biomaterial design.
Understanding the dynamic nature of amyloid formation is crucial for addressing associated diseases and creating new materials.

Purpose of the Study:

To review the conformational evolution of amyloid assemblies from initial phase separation to ordered structures.
To propose the concept of conformational evolution, highlighting structural transitions and selection pressures during amyloid assembly.

Main Methods:

Literature review of amyloid assembly pathways.
Analysis of evidence for structural transitions in amyloid assemblies.
Conceptual framework development for conformational evolution.

Main Results:

Amyloid formation progresses through distinct phases: liquid-liquid phase separation, oligomeric particles, and ordered assemblies.
Amyloid structures emerging from oligomeric phases may be unstable and undergo further transitions.
Structural mutations at fiber ends or surfaces are proposed to be under selection during assembly.

Conclusions:

The concept of conformational evolution provides a framework for understanding amyloid morphological diversity.
This framework has implications for developing targeted therapies for amyloid-related diseases.
Understanding conformational evolution is key to designing novel amyloid-based biomaterials.