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Poria cocos Wolf extracts represses pigmentation in vitro and in vivo

HyunKyung Lee1, Hwa Jun Cha2

  • 1GeneCellPharm Corporation, 2nd Enterprise Research Building, 194-41 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do 361-951, Republic of Korea.

Cellular and Molecular Biology (Noisy-Le-Grand, France)
|May 7, 2018
PubMed

Insights

Poria cocos Wolf extract inhibits melanin production by regulating tyrosinase and MITF expression, offering a potential cosmetic whitening agent. This extract also improved skin tone in a cream formulation.

Area of Science:

  • Dermatology
  • Cosmetic Science
  • Biochemistry

Background:

  • Melanocytes produce melanin, determining skin color and offering protection against UV damage.
  • Excessive melanin production leads to hyperpigmentation disorders like melasma and freckles.
  • Developing effective cosmetic whitening agents is crucial for addressing these conditions.

Purpose of the Study:

  • To investigate the efficacy of Poria cocos Wolf extracts as a potential skin whitening agent.
  • To elucidate the mechanism by which Poria cocos Wolf extracts inhibit melanogenesis.

Main Methods:

  • In vitro studies using B16F10 melanoma cells to assess melanin synthesis inhibition.
  • Analysis of tyrosinase activity and expression levels of tyrosinase and MITF (microphthalmia-associated transcription factor).
  • In vivo assessment of a Poria cocos Wolf extract-containing cream on skin tone improvement.

Main Results:

  • Poria cocos Wolf extracts significantly decreased melanin synthesis in B16F10 cells.
  • The extract regulated tyrosinase activity and reduced tyrosinase and MITF expression.
  • A cream formulation with Poria cocos Wolf extracts demonstrated improved skin brightness.

Conclusions:

  • Poria cocos Wolf extracts show significant potential as a cosmetic agent for skin whitening.
  • The mechanism involves the regulation of key factors in melanogenesis, including tyrosinase and MITF.
  • Further research supports its use in cosmetic products for hyperpigmentation management.
Keywords:
B16F10MITFMelanogenesisPoria cocos WolfTyrosinaseWhitening.

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