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Updated: Feb 11, 2026
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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
Published on: April 11, 2011
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C3 glomerulopathy associated with monoclonal Ig is a distinct subtype
Aishwarya Ravindran1, Fernando C Fervenza2, Richard J H Smith3
1Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Kidney International
|May 7, 2018
Summary
Monoclonal immunoglobulins (MIg) are linked to C3 glomerulopathy (C3G) in older adults. Targeted treatment for MIg may improve kidney function and achieve remission in some C3G patients.
Area of Science:
- Nephrology
- Immunology
- Complement System
Background:
- Monoclonal immunoglobulins (MIg) may impair complement alternative pathway regulation, potentially causing C3 glomerulopathy (C3G).
- C3G is a rare kidney disease often affecting older individuals.
Purpose of the Study:
- To investigate the role of MIg in C3G.
- To evaluate the effectiveness of MIg-targeted treatment in C3G patients.
Main Methods:
- Retrospective analysis of 95 C3G patients.
- Testing for MIg and associated hematologic conditions.
- Assessing renal function and treatment outcomes (MIg-targeted vs. non-targeted).
Main Results:
- 36% of C3G patients had MIg, predominantly in those aged 50+ (65.1%).
- MIg-targeted treatment led to hematologic response in 10/16 patients and renal response in 7/10.
- C3 nephritic factor was common (45.8%); pathogenic complement gene variants were rare.
Conclusions:
- MIg is a significant finding in older C3G patients.
- MIg-targeted therapy shows promise for improving renal outcomes in a subset of C3G patients.
- Further research is needed to elucidate the precise mechanisms and optimize treatment strategies.
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