Related Experiment Video

Updated: Feb 11, 2026

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

10.5K

Extralymphatic Disease Is an Independent Prognostic Factor in Hodgkin Lymphoma

Francesco Gaudio1, Pasquale Pedote2, Artor Niccoli Asabella3

  • 1Hematology Section, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy.

Clinical Lymphoma, Myeloma & Leukemia
|May 7, 2018
PubMed

Insights

Extralymphatic Hodgkin lymphoma is rare, affecting 16% of patients. This condition is linked to a poorer prognosis and lower complete remission rates compared to traditional lymphatic Hodgkin lymphoma.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • Hodgkin lymphoma (HL) typically involves lymph nodes.
  • Extranodal involvement, or extralymphatic disease, is less common but may impact prognosis.
  • Understanding the characteristics of extralymphatic HL is crucial for patient management.

Purpose of the Study:

  • To characterize the features of patients diagnosed with extralymphatic Hodgkin lymphoma.
  • To evaluate the clinical outcomes and prognostic factors associated with extralymphatic HL.

Main Methods:

  • A retrospective analysis was conducted on 341 Hodgkin lymphoma cases.
  • Patient data included demographics, disease site, and treatment outcomes.
  • Median follow-up was 44 months.

Main Results:

  • Extralymphatic disease was identified in 16% (55 out of 341) of patients.
  • Common extralymphatic sites included the lung (44%), bone (33%), liver (18%), and kidney (5%).
  • Patients with extralymphatic disease showed a poorer prognosis, with complete remission rates of 65% compared to 82% in the lymphatic disease group (P = .043).

Conclusions:

  • Extralymphatic Hodgkin lymphoma is an infrequent presentation associated with adverse clinical outcomes.
  • The presence of extralymphatic disease signifies a poorer prognosis in Hodgkin lymphoma patients.
  • Further research may be warranted to optimize treatment strategies for this subset of patients.
Abstract

Keywords:
ExtranodalLymphoprolipherative diseasePrognosisResponse rateSurvival

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

656
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K

Related Concept Videos

Introduction to Test of Independence01:21

Introduction to Test of Independence

In statistics, the term independence means that one can directly obtain the probability of any event involving both variables by multiplying their individual probabilities. Tests of independence are chi-square tests involving the use of a contingency table of observed (data) values.
The test statistic for a test of independence is similar to that of a goodness-of-fit test:
3.0K
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
8.2K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
1.4K
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.3K
Law of Independent Assortment02:03

Law of Independent Assortment

While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
62.8K
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
1.3K