Pharmacological investigations on anti-inflammatory activity of tryptamide (3-nicotinoyl-tryptamine)

The study concerned anti-inflammatory activity of a new tryptamine derivative - tryptamide. This preparation was effective in nonspecific inflammations and those involving immune mechanisms. Only postadjuvant inflammation appeared resistant to its effect. Its particular effectiveness was noted in the experimentally-induced iridocyclitis. Only in few tests, tryptamide was more effective than the reference drug phenylbutazone; in some cases the effect of both drugs was similar, but in the majority of cases tryptamide proved less effective.