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Dynamic thiol/disulphide homeostasis in children with febrile seizure

Aysegül Nese Citak Kurt1, Hatice Demir2, Alperen Aydin2

  • 1Department of Pediatric Neurology, Ankara Yıldırım Beyazıt University Yenimahalle Training and Research Hospital, Ankara, Turkey.

Seizure
|May 7, 2018
PubMed

Insights

Children with febrile seizures (FS) show an altered thiol/disulphide balance. This suggests that oxidative stress may play a role in the pathogenesis of febrile seizures in pediatric patients.

Area of Science:

  • Biochemistry
  • Pediatric Neurology

Background:

  • Febrile seizure (FS) is the most common seizure type in children.
  • The underlying mechanisms of FS remain incompletely understood.

Purpose of the Study:

  • To investigate the thiol/disulphide balance in children diagnosed with febrile seizures.
  • To explore the potential role of oxidative stress in FS pathogenesis.

Main Methods:

  • Compared 40 children with FS to 40 age and gender-matched controls.
  • Measured total thiol, native thiol, and disulphide levels.
  • Calculated thiol/disulphide ratios.

Main Results:

  • Native thiol levels were significantly lower in the FS group compared to controls (p=0.031).
  • Disulphide levels and disulphide/native thiol ratios were significantly higher in the FS group.
  • A shift in thiol/disulphide balance towards oxidants was observed in children with FS.

Conclusions:

  • The altered thiol/disulphide balance in FS suggests a potential role for oxidants in the condition's development.
  • Findings indicate that oxidative stress may be implicated in the pathogenesis of febrile seizures.
Abstract

Keywords:
Dynamic thiol/disulphide homeostasisFebrileSeizure

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