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Updated: Feb 11, 2026

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Myeloma light chain cast nephropathy, a review
Insara Jaffer Sathick1, Maria Eleni Drosou2, Nelson Leung3,4
1Renal Service, Division of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abstract:
Multiple Myeloma is a plasma cell proliferative disorder that commonly involves the kidney. Renal impairment is a serious complication during the course of the disease that is associated with increased morbidity and mortality. Light chain cast nephropathy is the predominant pattern of renal injury in Multiple Myeloma. This review article focuses on the pathophysiology and diagnostic approach of myeloma cast nephropathy. The management of precipitating factors as well as anti-plasma cell treatment modalities in the context of renal impairment are also discussed.
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