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Related Experiment Videos

Cutaneous reaction to contrast material.

B P Wood1, A T Lane, R Rabinowitz

  • 1Department of Radiology, University of Rochester Medical Center, NY 14642.

Radiology
|December 1, 1988
PubMed
Summary
This summary is machine-generated.

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Two children experienced skin reactions, resembling chemical burns, after voiding cystourethrography and intravenous urography using diatrizoate meglumine contrast media. This highlights a potential adverse reaction to urinary contrast agents.

Area of Science:

  • Pediatric Radiology
  • Dermatology
  • Pharmacovigilance

Background:

  • Voiding cystourethrography (VCUG) and intravenous urography (IVU) are common diagnostic imaging procedures in pediatrics.
  • Diatrizoate meglumine is a widely used iodinated contrast agent for these procedures.
  • Cutaneous adverse reactions to contrast media are typically associated with intravenous administration, not urinary tract exposure.

Observation:

  • Two pediatric patients developed localized skin reactions after undergoing VCUG and IVU.
  • The contrast material used was diatrizoate meglumine injection USP (18% for VCUG, 60% for IVU).
  • Reactions manifested as cutaneous bullae and erythema on the buttocks or foreskin approximately one hour post-urography.

Findings:

  • The observed cutaneous reactions mimicked superficial chemical burns.

Related Experiment Videos

  • This suggests a direct contact dermatitis or irritant reaction to diatrizoate meglumine present in the urine.
  • The reaction occurred in areas potentially exposed to urine containing the contrast agent.

    • Implications:

    • This case series suggests a potential for localized cutaneous reactions to diatrizoate meglumine in urine following genitourinary imaging.
    • Clinicians should be aware of this rare adverse event, particularly in pediatric patients.
    • Further investigation may be warranted to understand the mechanism and incidence of such reactions.