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Updated: Feb 11, 2026

Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment
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Large-Animal Model of Donation after Circulatory Death and Normothermic Regional Perfusion for Cardiac Assessment

Published on: May 10, 2022

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Human heart transplantation from donation after circulatory-determined death donors using normothermic regional

Simon Messer1, Aravinda Page1, Simon Colah1

  • 1Department of Transplantation, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridgeshire, UK.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|May 8, 2018
PubMed

Insights

Donation after circulatory-determined-death (DCD) heart transplantation is increasing. A new technique uses normothermic regional perfusion for assessment before cold storage, enabling successful DCD heart transplants.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Surgical Innovation

Background:

  • Donation after circulatory-determined-death (DCD) heart donation offers a potential to expand the donor pool for heart transplantation.
  • Established DCD heart retrieval methods include direct procurement with cold storage, direct procurement with machine perfusion, and normothermic regional perfusion (NRP) with transport perfusion.

Purpose of the Study:

  • To present a novel technique for DCD heart retrieval and transplantation.
  • To demonstrate the feasibility of using NRP for functional assessment of DCD hearts prior to transplantation.

Main Methods:

  • The study employed a technique involving normothermic regional perfusion (NRP) for DCD hearts.
  • This NRP phase allowed for functional assessment of the retrieved heart.
  • Following assessment, the heart was preserved using cold storage for transplantation.

Main Results:

  • Successful DCD heart transplantation was achieved using the described technique.
  • The method allowed for pre-transplant functional evaluation of the donor heart.
  • This approach expands the options for utilizing DCD hearts in transplantation.

Conclusions:

  • Normothermic regional perfusion followed by cold storage is a viable method for DCD heart retrieval.
  • This technique facilitates functional assessment, potentially improving outcomes in DCD heart transplantation.
  • The described approach contributes to increasing the utilization of DCD donors for heart transplantation.

Keywords:
donation after circulatory deathheartnormothermic regional perfusionorgan donationtransplant

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