Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Behavior?00:54

What is Behavior?

10.3K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Behaviorism01:28

Behaviorism

4.9K
The field of behaviorism was pioneered by figures such as Ivan Pavlov, John B. Watson, and B.F. Skinner fundamentally shifted the focus of psychology to the observable and controllable aspects of human and animal behavior. This shift marked a critical evolution in the discipline, emphasizing scientific rigor and experimental methodology.
The core premise of behaviorism is its focus on observable behavior rather than internal thoughts or feelings. This approach argues that true scientific...
4.9K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

1.4K
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
1.4K
Behavior Therapy01:22

Behavior Therapy

732
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
732
Plastic Behavior01:21

Plastic Behavior

581
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
581
Electron Behavior01:09

Electron Behavior

13.5K
Electrons are negatively charged subatomic particles attracted to and orbit around the positively-charged nucleus of an atom. They reside in spaces associated with energy levels called shells and are further organized into subshells and orbitals within each shell.
Electrons Orbit the Nucleus
Electrons are found in specific locations outside of the nucleus. The shell in which an electron resides indicates the general energy level of the electron: those closer to the nucleus have less energy,...
13.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thalamic nuclei insights into Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same author

Evidence from multifeature whole-report in visual short-term memory suggests that not all misbinding is swapping.

Scientific reports·2026
Same author

The Relationship Between Sleep, Cognition, and Dementia Risk in People With Focal Epilepsy.

Neurology·2026
Same author

Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.

Neuroscience and biobehavioral reviews·2026
Same author

The social dimension of apathy: evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders.

Translational psychiatry·2026
Same author

On the relationships between apathy, depression and anhedonia.

Journal of neurology, neurosurgery, and psychiatry·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
Same journal

Tracking Satb2-positive retinal ganglion cells in zebrafish unveils developmental functional reorganization.

Current biology : CB·2026
Same journal

RhoGAP54D promotes cell size asymmetry and inhibits pulsatile myosin activity in Drosophila neural stem cells.

Current biology : CB·2026
Same journal

Increased rates of hybridization in swordtails are associated with water pollution.

Current biology : CB·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.3K

Dopamine Modulates Option Generation for Behavior.

Yuen-Siang Ang1, Sanjay Manohar2, Olivia Plant3

  • 1Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Current Biology : CB
|May 8, 2018
PubMed
Summary
This summary is machine-generated.

Dopamine influences how people generate behavioral options, impacting both the number and uniqueness of choices. This research reveals dopamine

Keywords:
Parkinson’s diseaseapathycabergolinecreativitydecision makingdopamineoption generation

More Related Videos

Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
08:06

Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test

Published on: January 15, 2010

32.4K
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

20.0K

Related Experiment Videos

Last Updated: Feb 11, 2026

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

9.3K
Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test
08:06

Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test

Published on: January 15, 2010

32.4K
Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice
14:40

Optogenetic Manipulation of Neuronal Activity to Modulate Behavior in Freely Moving Mice

Published on: October 27, 2020

20.0K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Decision Science

Background:

  • Decision-making research often focuses on fixed options, with less understanding of how individuals generate novel behavioral choices.
  • Dopamine's role in modulating self-generated options is an area requiring further investigation.

Purpose of the Study:

  • To investigate the role of dopamine in the generation of behavioral options using a novel, objective task.
  • To quantify the trade-off between option fluency and uniqueness in healthy individuals and in response to dopaminergic modulation.

Main Methods:

  • Developed a quantitative, objective, and culture-fair task where participants drew paths between two points to measure option generation.
  • Compared option generation in healthy controls, Parkinson's disease patients ON and OFF medication, and healthy older adults receiving a D2 agonist (cabergoline).
  • Conducted control studies to rule out motor execution, action planning, or option selection as confounds.

Main Results:

  • Healthy individuals demonstrated a trade-off between generating many similar options (fluency) and few unique options.
  • Dopamine administration increased option fluency but decreased overall uniqueness due to the trade-off.
  • When the fluency-uniqueness trade-off was statistically controlled, dopamine was found to enhance option uniqueness.

Conclusions:

  • Dopamine plays a significant role in modulating the process of generating behavioral options.
  • The findings suggest that dopamine influences the exploration of behavioral possibilities, balancing quantity with novelty.
  • This research provides new insights into the neural mechanisms underlying creativity and adaptive decision-making.