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Updated: Feb 11, 2026
10:43
Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
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Elevated tissue nitric oxide in oral squamous cell carcinoma
Varsha A Sangle1, Smita J Chaware1, Meena A Kulkarni2
1Department of Oral Pathology and Microbiology, MIDSR Dental College, Ambajogai Road, Latur, Maharashtra, India.
Summary
Tissue nitric oxide (NO) levels are elevated in oral squamous cell carcinoma (OSCC) and correlate with advanced tumor stage and lower differentiation. This suggests NO plays a role in OSCC progression.
Area of Science:
- Oncology
- Biochemistry
- Oral Cancer Research
Background:
- Nitric oxide (NO) is implicated in oral squamous cell carcinoma (OSCC) progression.
- The precise mechanisms of NO's influence on tumor growth and behavior are not fully understood.
- Tumor biology and behavior are increasingly recognized as critical factors in cancer progression.
Purpose of the Study:
- To quantify tissue nitric oxide (NO) levels in OSCC patients.
- To investigate the correlation between tissue NO levels and the clinical grade and stage of OSCC.
Main Methods:
- Tissue samples from 42 OSCC patients and 42 healthy controls were analyzed.
- Nitric oxide levels were measured using a ultraviolet-visible spectrophotometer.
- Statistical analysis included Student's unpaired t-test and Tukey's post hoc analysis.
Main Results:
- Tissue NO levels were significantly higher in OSCC patients compared to the control group (P < 0.01).
- Elevated NO levels correlated positively with advanced clinical staging of the tumor.
- Increased NO levels were associated with decreased tumor cell differentiation.
Conclusions:
- Elevated tissue NO levels in OSCC patients are linked to tumor progression.
- The findings indicate a significant association between NO levels, tumor staging, and tumor grading in OSCC.
- Nitric oxide is recognized as a factor influencing tumor growth, staging, and grading in oral cancer.
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