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Oxidation Numbers03:14

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Related Experiment Video

Updated: Feb 11, 2026

Comet Assay as an Indirect Measure of Systemic Oxidative Stress
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Comet Assay as an Indirect Measure of Systemic Oxidative Stress

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Oxidative stress, aging, and diseases.

Ilaria Liguori1, Gennaro Russo1, Francesco Curcio1

  • 1Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.

Clinical Interventions in Aging
|May 8, 2018
PubMed
Summary

Oxidative stress, an imbalance in reactive oxygen and nitrogen species (RONS), contributes to aging and related diseases. Antioxidant therapies may help, but more research is needed to confirm their effectiveness.

Keywords:
antioxidantselderlyreactive nitrogen speciesreactive oxygen species

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Area of Science:

  • Biochemistry
  • Gerontology
  • Pathophysiology

Background:

  • Reactive oxygen and nitrogen species (RONS) are key players in cellular processes.
  • An imbalance between RONS production and antioxidant defenses leads to oxidative stress.
  • Oxidative stress is implicated in aging and various age-related diseases, including cardiovascular diseases, neurodegenerative disorders, and cancer.

Purpose of the Study:

  • To review the complex role of oxidative stress in aging and disease pathogenesis.
  • To explore the potential of antioxidant therapies in managing age-related conditions.
  • To highlight the significance of oxidative stress biomarkers in treatment efficacy and therapeutic targeting.

Main Methods:

  • Literature review of scientific articles on oxidative stress, aging, and antioxidant therapies.
  • Analysis of the pathophysiological mechanisms linking RONS, oxidative stress, and age-related diseases.
  • Examination of identified oxidative stress biomarkers and their clinical relevance.

Main Results:

  • Oxidative stress is a significant factor in age-associated functional decline.
  • Oxidative stress is intricately involved in the development of numerous chronic diseases.
  • Biomarkers of oxidative stress offer insights into treatment effectiveness and personalized medicine.

Conclusions:

  • Antioxidant interventions hold promise for mitigating the impact of oxidative stress in aging and disease.
  • Further clinical investigations are essential to validate the therapeutic efficacy of antioxidant strategies.
  • Understanding oxidative stress pathways is crucial for developing targeted treatments for age-related conditions.