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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Critical limb ischemia: current challenges and future prospects

Luigi Uccioli1, Marco Meloni1, Valentina Izzo1

  • 1Department of Systems Medicine.

Vascular Health and Risk Management
|May 8, 2018
PubMed

Insights

Critical limb ischemia (CLI), a severe peripheral artery disease, requires comprehensive management. This review covers its causes, diagnosis, and advanced treatments, including gene and cell therapies for difficult cases.

Area of Science:

  • Vascular Medicine
  • Cardiovascular Surgery
  • Regenerative Medicine

Background:

  • Critical limb ischemia (CLI) represents the most severe manifestation of peripheral artery disease (PAD).
  • CLI is characterized by chronic ischemic rest pain, ulceration, or gangrene due to peripheral arterial occlusion.
  • It carries a high risk of amputation, cardiovascular events, and mortality.

Purpose of the Study:

  • To provide a comprehensive overview of the pathophysiology, diagnosis, and holistic management of CLI.
  • To discuss advanced and unconventional treatment strategies for complex below-the-knee arterial disease.
  • To report on the current status of gene and cell therapy for CLI patients with limited options.

Main Methods:

  • Literature review focusing on CLI pathophysiology, diagnosis, and treatment modalities.
  • Analysis of conventional and unconventional revascularization techniques.
  • Review of current research and clinical applications of gene and cell therapy in CLI.

Main Results:

  • Revascularization is the primary treatment for CLI.
  • Conventional techniques are insufficient for certain complex below-the-knee arterial diseases.
  • Gene and cell therapies show promise for CLI patients deemed untreatable by standard methods.

Conclusions:

  • Effective management of CLI requires a multidisciplinary and holistic approach.
  • Unconventional techniques and emerging therapies like gene and cell therapy are crucial for managing complex CLI cases.
  • Further research into regenerative medicine holds potential for improving outcomes in CLI patients.

Keywords:
cell therapycritical limb ischemiamedical therapyperipheral arterial diseaserevascularization

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