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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
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Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis
Zhuoqiong Ren1,2, Yaou Liu1,2, Kuncheng Li1,2
1Xuanwu Hospital, Capital Medical University, Beijing, China.
Frontiers in Human Neuroscience
|May 8, 2018
Summary
Optic neuritis patients show altered brain activity, with functional impairment in the occipital lobe and adaptation in the frontal lobe. Relapsing optic neuritis indicates more severe damage correlated with disease duration.
Area of Science:
- Neuroscience
- Radiology
- Ophthalmology
Background:
- Optic neuritis (ON) is an inflammatory demyelinating disease of the optic nerve.
- Understanding spontaneous brain activity alterations in single (sON) and relapsing (rON) optic neuritis is crucial for disease management.
- Previous studies have not fully elucidated the functional changes in the brain associated with different forms of optic neuritis.
Purpose of the Study:
- To investigate spontaneous brain activity amplitude alterations in single and relapsing optic neuritis (sON and rON).
- To explore the relationships between these brain activity changes and clinical variables in optic neuritis patients.
- To compare brain activity patterns between sON, rON, and healthy controls.
Main Methods:
- Recruited 42 sON patients, 35 rON patients, and 50 healthy volunteers.
- Acquired resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans for all participants.
- Analyzed amplitude of low-frequency fluctuations (ALFFs) and correlated with clinical data (LogMAR, EDSS, disease duration).
Main Results:
- Both sON and rON patients exhibited decreased ALFFs in occipital and temporal lobes compared to controls.
- sON patients showed increased ALFFs in the left caudate and frontal lobes; rON patients showed increased ALFFs in the bilateral inferior temporal gyrus and left medial frontal gyrus.
- rON patients had significantly decreased ALFFs in the right inferior parietal lobule, left posterior cingulate, and precuneus compared to sON patients.
- Disease duration correlated with ALFF in several brain regions, including the middle temporal gyrus, inferior occipital gyrus, lingual gyrus, and inferior parietal lobule.
Conclusions:
- Spontaneous brain activity alterations, including functional impairment and adaptation, are present in both sON and rON.
- Occipital cortex is primarily affected by functional impairment, while the frontal lobe shows functional adaptations.
- Functional damage is more severe in rON patients than in sON patients and is associated with disease duration.
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