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Blood Lead Level in Children with Neurological Disorders

Marzieh Parhoudeh1, Soroor Inaloo1,2, Mozhgan Zahmatkeshan1

  • 1Department of Pediatrics, Shiraz University of Medical Sciences. Shiraz, Iran.

Iranian Journal of Child Neurology
|May 8, 2018
PubMed

Insights

Children with unexplained neurologic disorders had higher blood lead levels (BLL) than healthy children. Public health strategies should prioritize preventing lead exposure in pediatric populations.

Area of Science:

  • Environmental Health
  • Pediatric Neurology
  • Toxicology

Background:

  • Lead exposure is a significant environmental health concern.
  • Neurologic disorders in children can have various etiologies, including environmental factors.
  • Understanding the link between blood lead levels and pediatric neurologic conditions is crucial for public health.

Purpose of the Study:

  • To investigate blood lead levels (BLL) in children diagnosed with neurologic disorders of unknown causes.
  • To compare BLL in these children with age- and sex-matched healthy controls.
  • To identify potential associations between elevated BLL and pediatric neurologic conditions.

Main Methods:

  • A prospective case-control study involving 68 children with neurologic disorders and 68 healthy controls.
  • Participants aged 1 to 18 years were recruited from pediatric neurology clinics in Shiraz, Iran.
  • Blood lead levels were measured using venous blood samples, with ≥5 mcg/dl considered a toxic dose.

Main Results:

  • While mean BLL was slightly higher in the case group, the difference was not statistically significant (P=0.84).
  • However, the frequency of BLL ≥5 mcg/dl was significantly higher in children with neurologic disorders (P=0.024).
  • Children with neurologic disorders had an odds ratio of 2.9 for elevated BLL (≥5 mcg/dl) compared to controls.

Conclusions:

  • Elevated blood lead levels may be associated with unexplained neurologic disorders in children.
  • Public health initiatives should emphasize primary and secondary prevention of lead exposure in pediatric populations.
  • Further research is warranted to elucidate the causal relationship and specific mechanisms involved.
Abstract

Keywords:
Brain diseasesCerebral palsyEpilepsyLead poisoning

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