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Updated: Feb 11, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
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DWI - histology: a possible means of determining degree of liver fibrosis?

Niklas Verloh1, Kirsten Utpatel2, Michael Haimerl1

  • 1Department of Radiology, University Hospital Regensburg, Regensburg, Germany.

Oncotarget
|May 8, 2018
PubMed
Abstract

Insights

Diffusion-weighted MRI at 3 Tesla (3T) shows that liver fibrosis and cirrhosis reduce liver parenchyma ADC values. However, accurately classifying the fibrosis stage using ADC values requires further investigation.

Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatology

Background:

  • Liver fibrosis and cirrhosis are significant health concerns.
  • Accurate staging of liver fibrosis is crucial for patient management.
  • Diffusion-weighted MRI (DW-MRI) is a non-invasive imaging technique.

Purpose of the Study:

  • To evaluate the diagnostic utility of 3T DW-MRI for classifying liver fibrosis and cirrhosis.
  • To correlate apparent diffusion coefficient (ADC) values with histological fibrosis stages.

Main Methods:

  • 62 patients with histopathological examination and 3T DW-MRI of the liver.
  • Fibrosis staging using the Ishak score: No liver fibrosis (NLF), mild liver fibrosis (MLF), advanced liver fibrosis (ALF), and liver cirrhosis (LC).

Main Results:

  • ADC values decreased with increasing fibrosis: NLF (1123), MLF (1032), ALF (962), LC (1015) mm²/s.
  • Significant differences in ADC values were found between NLF and MLF (p=0.004) and between MLF and ALF (p=0.022).
  • No significant difference in ADC values was observed between ALF and LC (p=0.117).

Conclusions:

  • Liver fibrosis and cirrhosis are associated with reduced liver parenchyma ADC values on 3T MRI.
  • While ADC values decrease with fibrosis, their ability to precisely differentiate all stages of fibrosis, particularly advanced stages, is limited.
Keywords:
abdomenfibrosishistologylivermagnetic resonance imaging

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