Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improved predictive testing for Huntington disease by using three linked DNA markers.

M R Hayden1, C Robbins, D Allard

  • 1Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

American Journal of Human Genetics
|November 1, 1988
PubMed
Summary

Predictive testing for Huntington disease (HD) using linked DNA markers is informative for most at-risk individuals. This genetic testing can now estimate risk for about 75% of those seeking answers about HD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SmartAPPetite For Youth: pilot and feasibility study of an adolescent smartphone nutrition intervention.

Pilot and feasibility studies·2026
Same author

Clinical characteristics of women with HIV in the RESPOND cohort: A descriptive analysis and comparison to men.

HIV medicine·2024
Same author

Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression.

Cell cycle (Georgetown, Tex.)·2024
Same author

Epidemic Cholera.

Iowa medical journal·2023
Same author

Revulsion.

Iowa medical journal·2023
Same author

Highlights on the reversible nonpolar-to-polar <i>P</i>3<sub>1</sub>21-<i>P</i>3<sub>1</sub> phase transition at low temperature in NaLa(SO<sub>4</sub>)<sub>2</sub>·H<sub>2</sub>O: mechanism and piezoelectric properties.

Physical chemistry chemical physics : PCCP·2023

Area of Science:

  • Genetics
  • Neurology
  • Medical Diagnostics

Background:

  • Huntington disease (HD) is an inherited neurodegenerative disorder.
  • Predictive testing offers individuals at risk the possibility of knowing their genetic status.
  • Challenges in predictive testing include test informativeness and DNA availability.

Purpose of the Study:

  • To evaluate the informativeness of linked DNA markers for Huntington disease predictive testing.
  • To assess the impact of using multiple DNA markers on genetic risk estimation.
  • To determine the proportion of individuals who can receive actionable results from predictive testing.

Main Methods:

  • Enrollment of 85 individuals at risk for Huntington disease in a pilot program.
  • Determination of test informativeness using three linked DNA markers (D4S10, D4S62, D4S95) in 41 candidates.

Related Experiment Videos

  • Exclusion of 9% of candidates due to unavailability of crucial family DNA.
  • Analysis of results for 20 individuals who received their predictive test outcomes.

    • Main Results:

    • Test informativeness was achieved for 40 out of 41 (98%) candidates.
    • Only one candidate (2%) had an uninformative test result.
    • Of 20 individuals who received results, 12 (60%) had decreased risk and 8 (40%) had increased risk for HD.
    • Combined use of three DNA markers increased informativeness for approximately 75% of all predictive testing candidates.

    Conclusions:

    • Linked DNA marker analysis significantly enhances the informativeness of Huntington disease predictive testing.
    • The use of multiple DNA markers allows for a more accurate estimation of genetic risk for a majority of individuals.
    • Predictive testing provides valuable genetic risk information for individuals at risk of inheriting Huntington disease.