Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybridoma Technology01:31

Hybridoma Technology

17.8K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.8K
Response Surface Methodology01:16

Response Surface Methodology

674
Response Surface Methodology (RSM) is a collection of statistical and mathematical techniques used to develop, improve, and optimize processes. It is particularly valuable when many input variables or factors potentially influence a response variable.
The process of RSM involves several key steps:
674
Multi-input and Multi-variable systems01:22

Multi-input and Multi-variable systems

428
Cruise control systems in cars are designed as multi-input systems to maintain a driver's desired speed while compensating for external disturbances such as changes in terrain. The block diagram for a cruise control system typically includes two main inputs: the desired speed set by the driver and any external disturbances, such as the incline of the road. By adjusting the engine throttle, the system maintains the vehicle's speed as close to the desired value as possible.
In the absence of...
428
Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

3.4K
Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
3.4K
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Systematic Error: Methodological and Sampling Errors01:15

Systematic Error: Methodological and Sampling Errors

11.1K
In the case of systematic errors, the sources can be identified, and the errors can be subsequently minimized by addressing these sources. According to the source, systematic errors can be divided into sampling, instrumental, methodological, and personal errors.
Sampling errors originate from improper sampling methods or the wrong sample population. These errors can be minimized by refining the sampling strategy. Defective instruments or faulty calibrations are the sources of instrumental...
11.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leaf functional traits and their effects on photosynthetic carbon fixation of eight deciduous shrubs in urban parks.

Frontiers in plant science·2026
Same author

Aperture-collimated proton LATTICE radiotherapy with a GRID-like entrance pattern: a compact and robust delivery strategy.

Physics in medicine and biology·2026
Same author

A novel QA method for adaptive aperture position verification of proton therapy system.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2026
Same author

Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.

Investigative ophthalmology & visual science·2026
Same author

Lactoferrin Deficiency During Lactation Causes Adult Obesity-Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Dishevelled-mediated clustering stabilizes Frizzled6 and Vangl2 to establish planar cell polarity in the mammalian skin.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Feb 11, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.2K

Single Cell Multi-Omics Technology: Methodology and Application.

Youjin Hu1, Qin An2, Katherine Sheu2

  • 1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun-Ye-Sat University, Guangzhou, China.

Frontiers in Cell and Developmental Biology
|May 8, 2018
PubMed
Summary

Precision medicine utilizes multi-omics approaches to integrate diverse data, offering insights into disease. Single-cell multi-omics methods analyze transcriptome, genome, epigenome, and proteome for a comprehensive view of cellular mechanisms.

Keywords:
epigeneticsgene regulationsingle cell epigenomesingle cell multi-omics profilingsingle cell proteomesingle cell transcriptome

More Related Videos

Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments
09:12

Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments

Published on: October 4, 2021

3.8K
Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System
10:16

Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System

Published on: March 14, 2025

1.4K

Related Experiment Videos

Last Updated: Feb 11, 2026

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

2.2K
Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments
09:12

Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-Cell Multi-Omics Experiments

Published on: October 4, 2021

3.8K
Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System
10:16

Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System

Published on: March 14, 2025

1.4K

Area of Science:

  • Biotechnology
  • Genomics
  • Systems Biology

Background:

  • Precision medicine relies on integrating multi-omics data for disease insights.
  • Single-cell sequencing reveals cellular heterogeneity in health and disease.

Purpose of the Study:

  • To review state-of-the-art single-cell multi-omics methods.
  • To discuss applications, challenges, and future directions in the field.

Main Methods:

  • Development of modified and combined single-cell assays.
  • Simultaneous profiling of transcriptome, genome, epigenome, and proteome.
  • Analysis of regulatory mechanisms at single-cell resolution.

Main Results:

  • Single-cell multi-omics enables comprehensive study of cellular characteristics.
  • These approaches provide insight into combined regulatory mechanisms.
  • The review covers current methodologies and their utility.

Conclusions:

  • Single-cell multi-omics is a powerful tool for understanding complex biological systems.
  • Further advancements will enhance our grasp of disease mechanisms.
  • This technology is crucial for the future of precision medicine.