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Stability of potential renal acid load
Vickà Versele1, Peter Clarys1, Benedicte Deforche1,2
1Faculty of Physical Education and Physiotherapy, Department of Movement and Sport Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Summary
The potential renal acid load (PRAL) is not stable over 10 years, despite no change in average values. This suggests caution when interpreting long-term health outcomes based on initial PRAL measurements.
Area of Science:
- Nutrition science
- Dietary assessment
- Metabolic health
Background:
- The potential renal acid load (PRAL) is a dietary parameter used to estimate metabolic acid load.
- Longitudinal health studies often rely on baseline PRAL values, assuming stability over time.
- Understanding PRAL stability is crucial for accurate interpretation of long-term dietary impact on health.
Purpose of the Study:
- To assess the 10-year stability of the potential renal acid load (PRAL) and its dietary components.
- To evaluate the reliability of PRAL as a stable marker in longitudinal dietary studies.
Main Methods:
- Calculated PRAL from three-day dietary records of 197 women and 373 men at two time points (2002-2004 and 2012-2014).
- Employed Pearson and intra-class correlation coefficients to determine PRAL stability.
- Assessed agreement using kappa values and quintile changes over the 10-year period.
Main Results:
- No significant differences were observed in mean PRAL values between the two assessment periods.
- The stability of PRAL and its individual components over 10 years was found to be low.
- A poor agreement was noted between the two assessment moments, with most participants shifting to different PRAL quintiles.
Conclusions:
- The potential renal acid load (PRAL) demonstrated low stability over a 10-year period, based on dietary records.
- Findings indicate that PRAL calculated at baseline may not reliably represent long-term dietary acid load.
- Interpretation of longitudinal health outcomes associated with PRAL should be approached with caution due to its instability.
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