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Starvation tactics using natural compounds for advanced cancers: pharmacodynamics, clinical efficacy, and predictive

Khalid El Bairi1, Mariam Amrani2, Said Afqir3

  • 1Faculty of Medicine and Pharmacy, Mohamed Ist University, Oujda, Morocco.

Cancer Medicine
|May 8, 2018
PubMed

Insights

Natural compounds targeting tumor angiogenesis offer new hope for advanced cancers. Research highlights their potential as salvage treatments and discusses biomarkers for patient selection in clinical trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Advanced-stage cancers present significant mortality and management challenges.
  • Tumor angiogenesis is a key hallmark of cancer, driving metastasis and invasion.
  • Drug resistance necessitates novel therapeutic strategies, including natural compounds.

Purpose of the Study:

  • To review natural compounds investigated in clinical trials for advanced cancer treatment.
  • To discuss the role of these compounds in targeting tumor angiogenesis.
  • To explore predictive biomarkers for optimizing patient selection and treatment efficacy.

Main Methods:

  • Literature review of recent and ongoing clinical trials and real-world studies.
  • Analysis of natural compounds targeting angiogenesis as potential salvage therapies.
  • Discussion of predictive biomarkers for patient stratification.

Main Results:

  • Natural compounds targeting tumor vasculature are emerging as promising therapeutic options.
  • Clinical trials and real-world studies are evaluating their efficacy in advanced cancers.
  • Identification of predictive biomarkers is crucial for personalized treatment approaches.

Conclusions:

  • Natural compounds represent a valuable avenue for salvage treatment in advanced oncological diseases.
  • Targeting angiogenesis with natural agents holds significant potential for improving patient outcomes.
  • Biomarker-driven patient selection will optimize the use of these novel anticancer drugs.
Keywords:
advanced cancerangiogenesisclinical trialsdrug discoverynatural compoundspredictive biomarkersvascular disrupting agents

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