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Synthesis of Polyfunctionalized Triaryllanthanum Reagents by Using Ph3 La and Related Species as Exchange Reagents
Andreas D Benischke1, Lucile Anthore-Dalion1, Fabien Kohl1
1Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, Haus F, 81377, München, Germany.
Abstract:
Ph3 La⋅5 LiCl and the related (m-xylyl)3 La⋅5 LiCl were used as Hal/La exchange reagents (Hal=Br, I) for the preparation of various triaryl- and triheteroaryl-lanthanum derivatives. These new exchange reagents are compatible with isoquinolines and some functional groups such as a nitrile or an ester. The reactivity of the resulting lanthanum compounds towards electrophiles, such as ketones, aldehydes, N,N-dimethylamides, and primary alkyl halides was investigated. Additionally, a Pd-catalyzed cross-coupling procedure with aryl bromides was developed.
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