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IL-17A, MCP-1, CCR-2, and ABCA1 polymorphisms in children with non-alcoholic fatty liver disease

Ulas Emre Akbulut1, Hamdi Cihan Emeksiz2, Senol Citli3

  • 1University of Health Sciences, Antalya Education and Research Hospital, Department of Pediatric Gastroenterology Hepatology and Nutrition, Antalya, Turkey.

Jornal De Pediatria
|May 8, 2018
PubMed

Insights

Genetic variations in IL-17A may contribute to non-alcoholic fatty liver disease (NAFLD) in obese children. This study found a link between the IL-17A A-allele and NAFLD in Turkish children, suggesting a potential genetic predisposition.

Area of Science:

  • Pediatric Endocrinology
  • Hepatology
  • Genetics

Background:

  • Childhood obesity epidemic drives rising non-alcoholic fatty liver disease (NAFLD) prevalence.
  • NAFLD is associated with obesity, sedentary lifestyles, and genetic factors.
  • Understanding genetic predispositions is crucial for NAFLD management in children.

Purpose of the Study:

  • Investigate gene polymorphisms in obese Turkish children with NAFLD.
  • Specifically examine MCP-1, CCR-2, ABCA1, and IL-17A variants.
  • Determine potential genetic associations with NAFLD development.

Main Methods:

  • Recruited 186 obese children (10-17 years), including 101 with NAFLD.
  • Collected anthropometric data, biochemical markers (liver panel, lipids), and performed liver ultrasounds.
  • Genotyped four specific gene variants: MCP-1, CCR-2, ABCA1, and IL-17A.

Main Results:

  • No significant differences in BMI, waist/hip ratio, or body fat between groups.
  • Elevated ALT, AST, and GGT levels in the NAFLD group.
  • The A-allele of IL-17A (-197 G/A) (rs2275913) showed a significant association with NAFLD (OR 2.05, p=0.02).

Conclusions:

  • Suggests a potential association between IL-17A (-197 G/A) polymorphism and NAFLD in obese Turkish children.
  • Highlights the role of genetic variations in pediatric NAFLD.
  • Further research needed to confirm the role of IL-17A in NAFLD pathogenesis.
Abstract

Keywords:
ChildrenCriançasDoença hepáticaInterleucina 17Interleukin-17Liver diseaseObesidadeObesityPolimorfismos de nucleotídeo únicoSingle-nucleotide polymorphisms

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