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Interactions between model cell membranes and the neuroactive drug propofol

Petru Niga1, Petra M Hansson-Mille1, Agne Swerin2

  • 1RISE - Research Institute of Sweden, Bioscience and Materials - Surface, Process and Formulation Box 5607, SE-114 28 Stockholm, Sweden.

Journal of Colloid and Interface Science
|May 8, 2018
PubMed
Summary

Propofol, a common anesthetic, fluidizes phospholipid monolayers. However, it is squeezed out at biologically relevant pressures, suggesting a non-uniform distribution in cell membranes.

Keywords:
Langmuir troughModel membraneNeutron reflectometryPhospholipid monolayersPropofolSmall amphiphilic drugSurface pressure isothermVibrational sum frequency spectroscopy

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