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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Kidney Structure01:45

Kidney Structure

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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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What is Genetic Engineering?00:49

What is Genetic Engineering?

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Overview
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Related Experiment Video

Updated: Feb 11, 2026

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
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Cell Sheet Engineering and Kidney Diseases.

Masatoshi Oka, Yoei Miyabe, Naoko Sugiura

    Contributions to Nephrology
    |May 8, 2018
    PubMed
    Summary

    Cell sheet therapy offers a promising approach for treating organ damage by supplementing cells and providing therapeutic cytokines. This technology shows potential for kidney repair, promoting regeneration and function.

    Area of Science:

    • Regenerative Medicine
    • Tissue Engineering
    • Cell Therapy

    Background:

    • Cell sheet technology has demonstrated therapeutic efficacy across multiple organs, including the cornea, heart, and lungs.
    • Therapeutic benefits stem from cell supplementation and cytokine provision, promoting tissue repair via paracrine effects.
    • Traditional cell injection methods for renal repair have limitations in cell differentiation and complex tissue integration.

    Purpose of the Study:

    • To explore the potential of cell sheet therapy for kidney damage suppression.
    • To leverage the unique properties of 2D cell sheets for renal tissue repair.
    • To evaluate the suitability of cell sheet transplantation for complex organ structures like the kidney.

    Main Methods:

    • Review of existing literature on cell sheet transplantation in various organs.

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  • Analysis of the mechanisms underlying cell sheet therapy, including cell supplementation and paracrine signaling.
  • Assessment of the challenges and advantages of applying cell sheet technology to renal tissue.

    • Main Results:

    • Cell sheet transplantation effectively supplements cells and provides cytokines, aiding organ repair.
    • Paracrine effects from transplanted cells promote tissue regeneration.
    • 2D cell sheets are capable of producing essential proteins like erythropoietin, crucial for renal function.

    Conclusions:

    • Cell sheet therapy presents a viable strategy for organ repair due to its dual action of cell supplementation and cytokine delivery.
    • The 2D structure of cell sheets facilitates protein production and integration, making them suitable for complex organs.
    • Further development of cell sheet therapy is warranted to address kidney damage and enhance renal function.