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Understanding Resilience and Preventing and Treating PTSD.
1From the Department of Psychology, University of Oregon (Ms. Horn); Department of Psychiatry, Icahn School of Medicine at Mount Sinai (Dr. Feder).
Harvard Review of Psychiatry
|May 8, 2018
Summary
This review explores resilience, the ability to adapt to adversity. Research spans genetics, neurobiology, and interventions, offering new strategies for preventing and treating posttraumatic stress disorder (PTSD).
Area of Science:
- Psychology
- Neuroscience
- Genetics
Background:
- Resilience is the capacity to adapt to adversity, trauma, or threat.
- Early research focused on children, expanding to adults and interventions.
- Recent studies investigate genomic and neurobiological underpinnings of resilience.
Purpose of the Study:
- To review the multifaceted field of resilience research.
- To discuss the translation of resilience findings into preventive and treatment interventions.
- To highlight the potential for novel therapeutic strategies for posttraumatic stress disorder (PTSD).
Main Methods:
- Review of observational, intervention, genomic, and neurobiological studies.
- Examination of preclinical models of resilience.
- Synthesis of findings across psychosocial and neurobiological levels.
Main Results:
- Studies identify key early factors in children and adults.
- Genomic and neurobiological research reveals stress adaptation mechanisms.
- Interventions show promise in enhancing resilience in at-risk populations.
Conclusions:
- Knowledge of resilience mechanisms can inform new preventive strategies.
- Enhancing modifiable protective factors can improve PTSD treatment.
- Neurobiological insights offer novel therapeutic avenues for PTSD.
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