Related Experiment Videos
Trisomy 21q223 and Down's phenotype correlation evidenced by in situ hybridization
M C Pellissier1, M Laffage, N Philip
1Centre de Génétique Médicale et INSERM U.242, Hôpital d'Enfants de la Timone, Marseille, France.
Human Genetics
|November 1, 1988
Abstract:
Two cases of trisomy 21q223 with the Down's phenotype were analysed by in situ hybridization with specific probes previously located in the sub-bands 21q221 (SOD-A) and 21q223 (BCEI and COL6A). These studies give evidence that the clinical picture of Down's syndrome is at least to a great extent correlated with trisomy for the 21q223 band.